Scientists
SP1 - Marcus A. Glomb
Glycation alters the functionality of proteins during ageing
SP2 - Rüdiger Horstkorte, Heidi Olzscha
Acetylation and glycosylation in protein folding and misfolding: Impact on ageing-related diseases
SP3 - Thorsten Pfirrmann
The GID-complex as a regulator of cellular energy homeostasis and organismal longevity
SP7 - Anne Navarrete Santos
Investigation of histone modifications in stem cells from young and old donors: Impact of EZH2 O-GlcNAcylation on stem cell ageing
SP8 - Andreas Simm
Cellular and molecular impact of nuclear protein glycation
SP9 - Lars-Oliver Klotz
Protein glycation and glutathionylation as modulators of the activity of pro-ageing factors in C. elegans
SP10 - Christian A. Hübner
Age-dependent changes of the skeletal muscle glycome
SP11 - Claudia Großmann
Age-dependent impact of nitrosative stress-induced changes of mineralocorticoid receptor signalling
SP12 - Stefan H. Heinemann
Visualisation of protein modifications and their impact on the electrical signalling
SP13 - Regine Heller
AGE modifications in endothelial cells – functional characterisation and relevance for senescence and ageing
SP14 - Otmar Huber
The role of Nit1 in Wnt/b-catenin – FOXO signalling and ageing
SP15 - Alessandro Ori
Functional characterisation of AGE modifications in ageing
SP16 - Dan Rujescu
Glycosylation in Alzheimer-associated proteins in the context of microglia-mediated inflammation and disturbed blood-brain barrier functions
SP17 - Christoph Kaether
Role of Klotho in brain ageing
SP181 - Julia von Maltzahn
Molecular differences underlying functional impairment of aged muscle stem cells
SP192 - Steve Hoffmann
Bioinformatics analysis of transcriptional and epigenomic responses to posttranslational modifications
SP202,3 - Florian Meier, Darya Zibrova
Identification of novel O-GlcNAcylated substrates in endothelial cells and investigation of their role in senescence and ageing
SP212,3 - Patricia Franzka, Sonnhild Mittag, Christian Hübner
The role of GMPPA in the developing and ageing brain
1,2,3 These projects are associated with the RTG in the second-generation period (funding sources: JSMM (SP18), FLI (SP19), IZKF (SP20,21)) FLI - Leibniz Institute on Aging- Fritz Lipmann Institute; JSMM - Jena School of Molecular Medicine; IZKF - Interdisciplinary Centre of Clinical Research
